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Plateletalso called thrombocytecolourless, nonnucleated blood component that is important in the formation of blood clots coagulation. Platelets are found only in the blood of mammals. Platelets are formed when cytoplasmic fragments of megakaryocytes, which are very large cells in the bone marrowpinch off into the circulation as they age. They are stored in the spleen. Some evidence suggests platelets may also be produced or stored in the lungs, where megakaryocytes are frequently found.

Platelets play an important role in the formation of a blood clot by aggregating to block a cut blood vessel and provide a surface on which strands of fibrin form an organized clot, by contracting to pull the fibrin strands together to make the clot firm and permanent, and, perhaps most important, by providing or mediating a series of clotting factors necessary to the formation of the clot.

Platelets also store and transport several chemicals, including serotoninepinephrinehistamineand thromboxane; upon activation these molecules are released and initiate local blood vessel constriction, which facilitates clot formation. At birth the number of platelets is low, but by three months of age the adult level is reached. The number of platelets rises following trauma or asphyxiation, at high altitudes, after exerciseand in cold temperatures; the number may be temporarily lowered by menstruation in women.

Certain chemicals may prolong the life of platelets; smoking is believed to shorten their life spans. Article Media. Info Print Cite. Submit Feedback. Thank you for your feedback. The Editors of Encyclopaedia Britannica Encyclopaedia Britannica's editors oversee subject areas in which they have extensive knowledge, whether from years of experience gained by working on that content or via study for an advanced degree See Article History.

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Michael Flatley

Get exclusive access to content from our First Edition with your subscription. Subscribe today. Learn More in these related Britannica articles:. Although much more numeroustoper cubic millimetre than the white cells, they occupy a much smaller fraction of the volume of the…. Bleeding disorders may result from inherited or acquired defects of clotting or platelet function.

The usual consequence is persistent bleeding from injuries that would normally cause little trouble. Some persons may bleed more easily than normal, perhaps even spontaneously,….

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Mammalian platelets are nonnucleate cells produced by large bone marrow cells called megakaryocytes and circulate in the blood in a resting, inactive form for an average of 10 days. The normal platelet count in humans is betweenandplatelets…. History at your fingertips. Sign up here to see what happened On This Dayevery day in your inbox!

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Email address. By signing up, you agree to our Privacy Notice. Be on the lookout for your Britannica newsletter to get trusted stories delivered right to your inbox.Platelets are found only in mammals, whereas in other vertebrates e. The smear is used to examine platelets for size, shape, qualitative number, and clumping. A healthy adult typically has 10 to 20 times more red blood cells than platelets.

One major function of platelets is to contribute to hemostasis : the process of stopping bleeding at the site of interrupted endothelium. They gather at the site and, unless the interruption is physically too large, they plug the hole. First, platelets attach to substances outside the interrupted endothelium: adhesion.

Second, they change shape, turn on receptors and secrete chemical messengers: activation. Third, they connect to each other through receptor bridges: aggregation. These processes may overlap: the spectrum is from a predominantly platelet plug, or "white clot" to a predominantly fibrin, or "red clot" or the more typical mixture. Some would add the subsequent retraction and platelet inhibition as fourth and fifth steps to the completion of the process [7] and still others would add a sixth step, wound repair.

Platelets also participate in both innate [8] and adaptive [9] intravascular immune responses. The platelet cell membrane has receptors for collagen.

Following the rupture of the blood vessel wall, the platelets are exposed and they adhere to the collagen in the surrounding connective tissue. Low platelet concentration is called thrombocytopeniaand is due to either decreased production or increased destruction. Elevated platelet concentration is called thrombocytosisand is either congenitalreactive to cytokinesor due to unregulated production : one of the myeloproliferative neoplasms or certain other myeloid neoplasms.

A disorder of platelet function is a thrombocytopathy. This type of thrombosis arises by mechanisms different from those of a normal clot: namely, extending the fibrin of venous thrombosis ; extending an unstable or ruptured arterial plaque, causing arterial thrombosis ; and microcirculatory thrombosis. An arterial thrombus may partially obstruct blood flow, causing downstream ischemiaor may completely obstruct it, causing downstream tissue death.

Platelet concentration is measured either manually using a hemocytometeror by placing blood in an automated platelet analyzer using electrical impedancesuch as a Coulter counter. The normal range has been confirmed to be the same in the elderly [12] and Spanish populations. The number of platelets varies across individuals.

The normal physiologic range is to per microliter of blood. Since they contain receptors for thrombopoietin the protein that facilitates the maturation of megakaryocytes and release of plateletsa higher number of platelets binds more of the protein.People with depression and schizophrenia often show flat affect.

A person with schizophrenia may not show the signs of normal emotion, perhaps may speak in a monotonous voice, have diminished facial expressions, and appear extremely apathetic. Also known as blunted affect. Can flat feet be repaired by surgery?

So first of all check if it bothers you. There are different and treated differently. Ask an orthopedic. I think my son has flat foot, how to tell for sure? I didn't notice it before, he is 3 years old now and all shoes hurt him.

Does it mean he has flat foot?

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Pes planus flat foot is not a rare condition in toddlers, and may resolves spontaneously as the child grows. It is diagnosed clinically, i. Vox populi adjective Referring to a horizontal surface without irregularities or significant curvature. Level and smooth. Mentioned in? References in periodicals archive? Stairs rise up from the hall to the first floor landing which provides access to flatlets two and three, which benefit from a studio room, kitchen area and en suite shower room.

I would like to see flatlets provided at a very reduced rent, as a stepping-stone. Interview: Hilary Burnham - Doughty battler on behalf of racing's unsung heroes; David Ashforth talks to Lady Hilary Burnham, a thoughtful reformer with a genuine concern for stable staff.

A partnership between Hanover Housing Association, Strathclyde Regional Council, East Renfrewshire Council, the Health Board and Scottish Homes, Waterford Court offers 13 self-contained flatlets with a communal lounge, dining room, a quiet room and a suite for guests. Two to One.

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One should spare a thought for some, mostly young, victims of the surge in housing prices in the s, who rushed to buy small, often shoddy, 'studios' and ' flatlets ', which in a more stable market are proving unsaleable. Development in the English countryside. At Newport Juvenile Court today the boys, aged 10 and 12, admitted breaking into Dolgelly, a Caerau Road, Newport, house converted into a showpiece flatlets for old folk.

Court in Brief. They helped to organise holidays for disadvantaged children, provision for clothing, halfway houses for boys coming out of borstal, meals on wheels and flatlets for young women. Tribute to unsung WVS heroines; A new archive has been released, showing the extent to which Birmingham's women played a part in winning the war. Conwy Council wants Mike and Jan Singleton to replace the eleven windows of their apartment in a converted former holiday flatlets at Balmoral Building, Trinity Square, Llandudno.

Mr Squire said yesterday: "I am pleased the regeneration scheme is going to involve the demolition of some bedsits and flatlets.

Mr Adabuga - the man behind Ghana’s 1981 coup exposes Rawlings

Medical browser? Full browser?Michael Ryan Flatley born July 16, is an Irish-American former dancer, choreographer, and musician. Flatley is credited with reinventing traditional Irish dance by incorporating new rhythms, syncopation, and upper body movements, which were previously absent from the dance.

Flatley retired in due to constant spinal, knee, foot, and rib pain. Flatley is a native of South Side, Chicago. He is of Irish ancestry. Michael Sr. His grandmother, Hannah Ryan, was a champion dancer. Beginning in the late s, when Flatley was 11 years old, he was taught dance by Dennis G. Also inFlatley competed in the amateur boxing Chicago Golden Gloves tournament in the pound novice division; however, he lost to Kenneth Reed on February After graduating high school, Flatley worked as a stockbroker, a blackjack gambler, and a flutist.

The show was produced by Moya Dohertywith principal choreography by Flatley and lead performances by Flatley and Butler. In Septemberafter the show sold out, Flatley left Riverdance to pursue what would eventually become Lord of the Dance.

Flatley had been in a dispute with the producers over his salary and royalty fees. He was fired the night before the show was set to open in London and replaced with Colin Dunne. That's all. I don't think that that's too much to ask. I felt like I built it and they took it, and that's the end of it Immediately after the Riverdance split, Flatley decided to create his own show, Lord of the Dancewhich was capable of playing in arenas and stadiums aside from traditional theaters.

InFlatley created an expanded version of the show called Feet of Flames which served as its one-off performance and his final performance in Lord of the Dance. It was performed outdoors in the Rotten Row area of Hyde Park, London on a gigantic 4-tier hydraulic stage, with a live band, and over dancers performing on all four levels of the stage during the finale.

Ronan Hardiman's music from the original Lord of the Dance was used again along with new compositions, also by Hardiman himself. Following the success of the Hyde Park show, Flatley produced another version of Feet of Flames inwhich included half of the original show and half new material. Flatley's next show, Celtic Tiger Liveopened in July The show explores the history of the Irish people and Irish emigration to the U.Chiefly British An efficiency apartment. Switch to new thesaurus. Mentioned in?

References in periodicals archive? According to this fact that the orthogonal polynomials play an important role to solve integral and differential equations, many researchers constructed operational matrix of fractional and integer derivatives for some types of these polynomials, such as Flatlet oblique multiwavelets [17, 18], B-spline cardinal functions [19], Legendre polynomials, Chebyshev polynomials, and CAS wavelets [20].

Upstairs on the first floor, one of the front rooms has been converted to a kitchenette and dining area, a useful facility that, together with a bedroom, could be used to create a self-contained flatlet. There are four double bedrooms on this floor. Superb home has power to impress.

Costa del Dream; Turn your holiday hope into a reality. TJ T tjthomas. Kayte inside the School Gate. Each two-bedroomed flatlet in the walled garden plot is almost complete after a long period of development by Coventry builder Hall Brothers of Wyken. So happy local eyesore has gone. At a school for troubled children he blossomed, doing well at IT, maths and English but his life fell apart again when he moved into a hostel's flatlet. Garden of freedom.

Dictionary browser? Full browser?When it comes to shipping freight, there are a multitude of different options, and narrowing the field down to just one can be confusing. There are many different factors to consider including price, the type of shipment, the size of shipment, and the speed in which the shipment needs to be delivered.

LTL shipping stands for less than truckload, meaning that the shipment will not take up an entire truck. These types of shipments typically weigh between and 10, pounds. With an LTL shipment, you only pay for the space in the truck that you need.

For example, if your shipment only takes up one-third of the space on the truck, you only pay for one-third of the truck. LTL freight shipments will often take a bit longer to reach their destinations, due to the multiple shipments on board creating frequent stops. If time is of the essence, you may want to consider FTL shipping. FTL shipping stands for full truckload, meaning that the shipment will take up an entire truck by itself. FTL shipments are typically used when there are ten or more palettes that need to ship.

If your shipment is high-risk, FTL may be the better option. When deciding on the most appropriate type of shipment for your freight, always keep in mind the size of your shipment, your budget, how fragile the freight is, and how quickly you need your shipment to reach its destination. If your shipment is small, sturdy, and not in a time crunch, LTL will fit your needs.

We aim to provide the most efficient and economical shipping for all of our clients, and work with a number of servicers to ensure you get only the best rates no matter your shipping needs. We take care of the details both big and small, so you can rest easy with your shipments in our hands.

Full Truckload Less Than Truckload.Add flatlet to one of your lists below, or create a new one. Sparkling and dazzling! Words related to light, Part 1. Definitions Clear explanations of natural written and spoken English. Click on the arrows to change the translation direction.

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Clear explanations of natural written and spoken English. Word Lists. Choose your language. My word lists. Tell us about this example sentence:. The word in the example sentence does not match the entry word. The sentence contains offensive content. Cancel Submit. Your feedback will be reviewed. Examples of flatlet. A growing number of small hotels are converting to rest homes for the elderly or into holiday flatlets. From the Hansard archive. Example from the Hansard archive.

Contains Parliamentary information licensed under the Open Parliament Licence v3. These were houses, bungalows, purpose-built flats, converted flats, maisonettes, town houses, mews houses, semi-houses and flatlet houses. These examples are from the Cambridge English Corpus and from sources on the web. Any opinions in the examples do not represent the opinion of the Cambridge Dictionary editors or of Cambridge University Press or its licensors.

Clearly, as associations successfully convert this dilapidated housing into flats and flatlets, less become available for alternative uses.

I was speaking of small one-bedroom flatlets within a block. That is what the holiday flatlet owners have tried to do. The argument involved the cost of converting the rooms into proper flatlets. There are many parts of the country where large houses have been converted into flats and flatlets. What has happened is that people are now taking holidays in flatlets or in caravans rather than in hotels.

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